Adrenal cancer is a rare disease that originates in the adrenal glands. The adrenal glands are located on top of the kidneys and consist of two parts that function separately: the outer layer (cortex) and the inner area (medulla). The cortex produces three major hormones. Adrenal tumors can increase hormone production called functioning tumors. Adrenal tumors that do not produce hormones are called nonfunctioning tumors. Symptoms of adrenal cancer and treatment for this condition depend on whether the tumor is functioning or nonfunctioning and on which hormone is being overproduced.